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        師資隊伍
        人才風采 云大首頁 > 師資隊伍 > 人才風采 > 正文

        張建

        發布時間:2018年03月29日        點擊量:

           

         

        張建,教授,博士,云南大學生命科學學院副院長,云南大學生命科學研究中心副主任,博士生導師。


        教育與研究經歷:

        1988年獲四川大學學士;

        1996年獲University of Miami 博士學位;

        1997-1999年,University of Miami 和Genentech Inc. 博士后;

        2003-2016年,中國科學院遺傳與發育生物學研究所,研究員;

        2016年 -  云南大學生命科學院, 教授;

        2003年 中國科學院“百人計劃”入選者;

        2004年 國家自然科學基金委員會 “杰出青年基金”獲得者;

        目前任Biology of the Cell主編,Journal of Genetics and Genomics 編委,Science in China, Life Science 編委。

        研究方向與成果

         

        張建教授長期從事脊椎動物早期胚胎發育的研究,主要研究母源因子在早期發育中的功能。 其中發現非洲爪蛙中參與中內胚層發育的主控基因VegT并研究了其調控機制,是早期胚胎發育重要的工作之一,在領域內產生重要影響。發現母源xNorrin是決定神經外胚層發育的關鍵基因,研究了Norrin與Wnt和TGF-beta信號通路的調控關系,揭示了人類Norrie疾病特定病人群致病的分子新機制。近年來主要開展斑馬魚和小鼠早期發育的研究, 集中研究細胞譜系(如:原始生殖細胞)建立等。 研究成果發表在Cell, PLOS Biology, Development, PNAS, Journal of Neuroscience等國際學術期刊上。

           

        代表性論文:

         

        1.Zhu DM, Gong X, Fang JS, Zhang Jian*. (2017) Efficient Induction of Syncytiotrophoblast Layer II Cells from Trophoblast Stem Cells by Canonical Wnt Signaling Activation. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2017.10.014

        2.Miao LY, Yuan Y, Cheng F, Fang JS, Zhou F, Ma WR, Huang XH, Wang YC, Chen DH, Zhang Jian*. (2017) Translation Repression by Maternal RNA Binding Protein Zar1 is Essential for Early Oogenesis in Zebrafish. Development. 144(1):128-138

        3.Cheng F, Miao L, Wu Q, Gong X, Xiong J*, Zhang Jian*. (2016) Vinculin b deficiency causes epicardial hyperplasia and coronary vessel disorganization in zebrafish.Development 143(19):3522-3531.

        4.Fang J, Wang H, Miao L, Kuang X, Ma W, Wang C, Zhang Jian*, Xia G*. (2016) Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis. Biol. Reprod. 95(3):67.

        5.Ma W., Zhang Jian*. (2015) Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death. Development 142, 763-773.

        6.W. Su, J. Fang, F. Cheng, C. Liu, F. Zhou, Zhang Jian*. (2013) RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development. Proc Natl Acad Sci U S A 110(5):1720-5.

        7.C. Liu, W. Ma, W. Su, Zhang Jian*. (2012) Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish. Development 139(24):4591-600.

        8.HW. Wang, JS. Fang, X. Kuang, LY. Miao, C. Wang, GL. Xia, ML. King, Zhang Jian*. (2012) Activity of long-chain acyl-CoA synthetase is required for maintaining meiotic arrest in Xenopus laevis. Biol. Reprod. 87(3):74 .

        9.S. Xu, F. Cheng, J. Liang, W. Wu, Zhang Jian*. Maternal xNorrin, a Canonical Wnt Signaling Agonist and TGF-b Antagonist, Controls Early Neuroectoderm Specification in Xenopus. PLOS Biology. 10(3): e1001286 (2012).

        10.Zhang L, Zheng S, Wu H, Wu Y, Liu S, Fan M, Zhang Jian.* (2009) Identification of BLyS (B lymphocyte stimulator), a non-myelin-associated protein, as a functional ligand for Nogo-66 receptor. J. Neurosci. 29(19): 6348-52.

        11.Zhang, J., Houston, D.W., King, M. L., Payne, C., Wylie, C., and Heasman, J. (1998) The role of maternal VegT in establishing the primary germ layers in Xenopus embryos. Cell 94, 515-524.

        12.Zhang, Jian. and King, M.L. (1996) Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcriptional factor involved in dorsal/ventral patterning. Development 122, 4119-41.

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